Journal
EXPERIMENTAL CELL RESEARCH
Volume 318, Issue 12, Pages 1428-1434Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2012.03.028
Keywords
Actin dynamics; Cell division; Cell mechanics; Cleavage furrow; Mechanosensation; Myosin II
Categories
Funding
- National Institutes of Health [GM066817, GM086704]
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Cytokinesis, the physical separation of a mother cell into two daughter cells, progresses through a series of well-defined changes in morphology. These changes involve distinct biochemical and mechanical processes. Here, we review the mechanical features of cells during cytokinesis, discussing both the material properties as well as sources of stresses, both active and passive, which lead to the observed changes in morphology. We also describe a mechanosensory feedback control system that regulates protein localization and shape progression during cytokinesis. (c) 2012 Elsevier Inc. All rights reserved.
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