Journal
EXPERIMENTAL CELL RESEARCH
Volume 318, Issue 9, Pages 1011-1019Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2012.02.024
Keywords
Epithelial Na+ channel; Fluid volume; Regulation; Protein kinases; Phosphatidylinositol
Categories
Funding
- National Institutes of Health [DK051391, DK065161, DK078734, DK079307]
- Pittsburgh Center for Kidney Research
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Electrogenic Na+ transport across high resistance epithelial is mediated by the epithelial Na+ channel (ENaC). Our understanding of the mechanisms of ENaC regulation has continued to evolve over the two decades following the cloning of ENaC subunits. This review highlights many of the cellular and extracellular factors that regulate channel trafficking or gating. (C) 2012 Published by Elsevier Inc.
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