Journal
EXPERIMENTAL CELL RESEARCH
Volume 317, Issue 9, Pages 1255-1260Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2011.03.010
Keywords
Bispecific; Antibody; BiTE
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Severe side effects and few long-term remissions frequently limit the treatment of advanced malignant diseases. Bispecific antibodies are currently emerging as a new option for the treatment of malignant diseases, which can potentially engage all cytotoxic T cells of a patient for tumor cell lysis. Blinatumomab, a bispecific single-chain BiTE antibody construct with dual specificity for CD19 and CD3, is a front runner of this antibody class. We here summarize the current state of development of blinatumomab for the treatment of patients with B-cell non-Hodgkin's lymphoma (NHL) and B-precursor acute lymphocytic leukemia (ALL). High response rates and durable remissions are observed in first clinical trials, indicating that T cells can be potently redirected for efficient and lasting elimination of malignant cells. (C) 2011 Elsevier Inc. All rights reserved.
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