Journal
EXPERIMENTAL CELL RESEARCH
Volume 317, Issue 5, Pages 664-673Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2010.11.013
Keywords
Chemokines; Receptors; Cancer; Inflammation; Macrophages
Categories
Funding
- Italian Association for Cancer Research (AIRC) Italy
- FP6 European Programme ATTACK
- FP7 European People Programme ATTRACT
- Italian Ministry of Health, University and Research
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Chemokines are key players of the cancer-related inflammation. Chemokine ligands and receptors are downstream of genetic events that cause neoplastic transformation and are abundantly expressed in chronic inflammatory conditions which predispose to cancer. Components of the chemokine system affect multiple pathways of tumor progression including: leukocyte recruitment, neo-angiogenesis, tumor cell proliferation and survival, invasion and metastasis. Evidence in pre-clinical and clinical settings suggests that the chemokine system represents a valuable target for the development of innovative therapeutic strategies (C) 2010 Elsevier Inc. All rights reserved.
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