Journal
EXPERIMENTAL CELL RESEARCH
Volume 317, Issue 5, Pages 685-690Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2010.10.020
Keywords
Chemokines; Angiogenesis; Cancer
Categories
Funding
- National Institutes of Health [HL97074, HL73848, CA87879, HL66027, HL98526]
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Chemokines are a superfamily of structurally homologous heparin-binding proteins that influence tumor growth and metastasis. Several members of the CXC and CC chemokine families are potent inducers of neovascularization, whereas a subset of the CXC chemokines are potent inhibitors. In this paper, we review the current literature regarding the role of chemokines as mediators of tumor angiogenesis and neovascularization. (C) 2010 Elsevier Inc. All rights reserved.
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