Journal
EXPERIMENTAL CELL RESEARCH
Volume 316, Issue 8, Pages 1397-1407Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2010.02.042
Keywords
Melanocytes; Neural crest; Pigmentation; Cell migration; Schwann cell precursors; Schwann cells
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Melanocytes are derived from the neural crest (NC), which are transient multipotent cells arising by delamination from the developing dorsal neural tube. During recent years, signaling systems and molecular mechanisms of melanocyte development have been studied in detail, but the exact diversification of the NC into melanocytes and how they migrate, expand and disperse in the skin have not been fully understood. The recent finding that Schwann cell precursors (SCPs) of the growing nerve represents a stem cell niche from which various cell types, including Schwann cells, endoneural fibroblasts and melanocytes arise has exposed new knowledge on the cellular basis for melanocyte development. This opens for the identification of new factors and reinterpretation of old data on cell fate instructive, proliferative, survival and cell homing factors participating in melanocyte development. (C) 2010 Elsevier Inc. All rights reserved.
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