Journal
EXPERIMENTAL CELL RESEARCH
Volume 315, Issue 4, Pages 619-626Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2008.07.025
Keywords
HB-EGF; ErbB; Blastocyst; Implantation
Categories
Funding
- Korea Research Foundation
- Korean Government (MCEHRD, Basic Research Promotion Fund) [KRF-2007-313-C00607]
- National Institute of Child Health & Human Development [HD12304]
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An implantation-competent blastocyst, several hours prior to its attachment on the uterine wall, transmits signals to surrounding uterine cells and vice-versa to initiate a two-way interaction. The language of this precocious dialogue is versatile, taking advantage of secreted molecules for longrange interactions and membrane-bound molecules for more immediate interactions. Heparinbinding epidermal growth factor-like growth factor (HB-EGF) was identified as an early messenger of implantation which uses both modes of communication. In this review, we discuss the footprint of HB-EGF as to how it was initially identified as a mediator of implantation and how it initiates embryo-uterine interactions during this process. (C) 2008 Elsevier Inc. All rights reserved.
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