Journal
EXPERIMENTAL CELL RESEARCH
Volume 315, Issue 7, Pages 1148-1156Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2008.11.010
Keywords
Anoikis; Apoptosis; Metastasis; TRAIL; Cancer
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Funding
- National Natural Science Foundation of China [30700357, 30772031, 30700973, 30873025]
- Natural Science Foundation of Shandong Province, PR China [Q2006C06]
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Acquisition of anoikis-resistance is a pre-requisite for cancer cell metastasis. We have demonstrated that hepatoma cells could resist anoikis by a synoikis-like survival style. In this study, we further suggest that acquisition of anoikis-resistance confer cancer cells more capacity for invasiveness, evading from cancer therapeutic agents and escaping from host immune attacks. We investigated the response of anoikis-resistant hepatoma cells to TNF-related apoptosis-inducing ligand (TRAIL), a typical immune surveillant molecule as well as a potential anticancer agent. Our data indicated that detached hepatoma cells not only resist TRAIL-induced apoptosis, but also domesticate TRAIL to exert a stealth tumor counterattack effect. These results reveal that acquisition of anoikis-resistance may act as a selective pressure to superimpose on hepatoma cells more metastatic potential for the development of cancer. (C) 2009 Elsevier Inc. All rights reserved.
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