Journal
EXPERIMENTAL CELL RESEARCH
Volume 315, Issue 4, Pages 671-682Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2008.10.011
Keywords
ErbB receptor; Protease; Cleavage; Signal transduction
Categories
Funding
- NIH [CA125649, GM647450, EY015719]
- Medical Research Council [MC_U105178780] Funding Source: researchfish
- MRC [MC_U105178780] Funding Source: UKRI
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Proteases are now recognized as having an active role in a variety of processes aside from their recognized metabolic role in protein degradation. Within the ErbB system of ligands and receptors, proteases are known to be necessary for the generation of soluble ligands from transmembrane precursors and for the processing of the ErbB4 receptor, such that its intracellular domain is translocated to the nucleus. There are two protease activities involved in the events: proteases that cleave within the ectodomain of ligand (or receptor) and proteases that cleave the substrate within the transmembrane domain. The former are the ADAM proteases and the latter are the gamma-secretase complex and the rhomboid proteases. This review discusses the roles of each of these protease systems within the ErbB system. (C) 2008 Elsevier Inc. All rights reserved.
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