Journal
EXPERIMENTAL CELL RESEARCH
Volume 315, Issue 5, Pages 727-732Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2008.09.017
Keywords
Insulin
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This review focuses on IRS-1 and the evidence of its role in cell transformation. The literature strongly suggests that IRS-1 Should be considered a biomaker for cancers Susceptible to IGF-IR targeting. In addition, I Would like to propose that IRS-1 may have a more general role in cancer, and could be considered as a protein having the opposite effect Of tumor Suppressors, a Sort of anti-p53 molecule. (C) 2008 Published by Elsevier Inc.
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