Journal
EXPERIMENTAL CELL RESEARCH
Volume 314, Issue 9, Pages 1909-1917Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2008.02.023
Keywords
epigenetics; chromatin; aging; longevity; cell senescence
Categories
Funding
- NCI NIH HHS [R01 CA129334, R01 CA129334-01A1, R01 CA129334-01] Funding Source: Medline
- NIA NIH HHS [R01 AG016694, R01 AG016694-10, P01AG031862, P01 AG031862] Funding Source: Medline
- NIGMS NIH HHS [R01 GM062281-08, R01 GM062281, R01 GM041690, R01 GM041690-18] Funding Source: Medline
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Chromatin structure is not fixed. Instead, chromatin is dynamic and is subject to extensive developmental and age-associated remodeling. in some cases, this remodeling appears to counter the aging and age-associated diseases, such as cancer, and extend organismal lifespan. However, stochastic non-deterministic changes in chromatin structure might, over time, also contribute to the break down of nuclear, cell and tissue function, and consequently aging and age-associated diseases. (C) 2008 Elsevier Inc. All rights reserved.
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