Journal
EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 239, Issue 6, Pages 647-662Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1535370214522935
Keywords
Nitration; nitrosation; nitrosative signaling; cardioprotection; ischemia; reperfusion
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Funding
- Italian Ministry of the University and Research (MIUR)
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The coronary artery disease is a leading cause of death and morbidity worldwide. This disease has a complex pathophysiology that includes multiple mechanisms. Among these is the oxidative/nitrosative stress. Paradoxically, oxidative/nitrosative signaling plays a major role in cardioprotection against ischemia/reperfusion injury. In this context, the gas transmitter nitric oxide may act through several mechanisms, such as guanylyl cyclase activation and via S-nitrosylation of proteins. The latter is a covalent modification of a protein cysteine thiol by a nitric oxide-group that generates an S-nitrosothiol. Here, we report data showing that nitric oxide and S-nitrosylation of proteins play a pivotal role not only in preconditioning but also in postconditioning cardioprotection.
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