Journal
EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 240, Issue 5, Pages 593-600Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1535370214560957
Keywords
Copolymer; hydrogel; mesenchymal stem cells; myocardial infarction; cardiac repair
Categories
Funding
- National Science Foundation of China [81000042, 81270326, 81301312]
- Shanghai Science Foundation [10ZR1406200]
Ask authors/readers for more resources
Mesenchymal stem cell (MSC) transplantation by intramyocardial injection has been proposed as a promising therapy strategy for cardiac repair after myocardium infarction. However, low retention and survival of grafted MSCs hinder its further application. In this study, copolymer with N-isopropylacrylamide/acrylic acid/2-hydroxylethyl methacrylate-poly(epsilon-caprolactone) ratio of 88:9.6:2.4 was bioconjugated with type I collagen to construct a novel injectable thermosensitive hydrogel. The injectable and biocompatible hydrogel-mediated MSC transplantation could enhance the grafted cell survival in the myocardium, which contributed to the increased neovascularization, decreased interstitial fibrosis, and ultimately improved heart function to a significantly greater degree than regular MSC transplantation. We suggest that this novel hydrogel has the potential for future stem cell transplantation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available