Journal
EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 240, Issue 10, Pages 1352-1361Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1535370214561958
Keywords
Polydatin; cardiac hypertrophy; angiotensin II; reactive oxygen species; NADPH oxidase
Categories
Funding
- National Natural Science Foundation of China [31171101, 81100175]
- Key Project of Chinese Ministry of Education [212173]
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Our studies and others recently demonstrate that polydatin, a resveratrol glucoside, has antioxidative and cardioprotective effects. This study aims to investigate the direct effects of polydatin on Ang II-induced cardiac hypertrophy to explore the potential role of polydatin in cardioprotection. Our results showed that in primary cultured cardiomyocytes, polydatin blocked Ang II-induced cardiac hypertrophy in a dose-dependent manner, which were associated with reduction in the cell surface area and [H-3] leucine incorporation, as well as attenuation of the mRNA expressions of atrial natriuretic factor and beta-myosin heavy chain. Furthermore, polydatin prevented rat cardiac hypertrophy induced by Ang II infusion, as assessed by heart weight-to-body weight ratio, cross-sectional area of cardiomyocyte, and gene expression of hypertrophic markers. Further investigation demonstrated that polydatin attenuated the Ang II-induced increase in the reactive oxygen species levels and NADPH oxidase activity in vivo and in vitro. Polydatin also blocked the Ang II-stimulated increases of Nox4 and Nox2 expression in cultured cardiomyocytes and the hearts of Ang II-infused rats. Our results indicate that polydatin has the potential to protect against Ang II-mediated cardiac hypertrophy through suppression of NADPH oxidase activity and superoxide production. These observations may shed new light on the understanding of the cardioprotective effect of polydatin.
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