Journal
EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 237, Issue 11, Pages 1241-1248Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1258/ebm.2012.012180
Keywords
light therapy; mechanism; photobiomodulation; laser therapy; low-level laser therapy; low-level light therapy
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Five decades after the first documented use of a laser for wound healing, research in light therapy has yet to elucidate the underlying biochemical pathways causing its effects. The aim of this review is to summarize the current research into the biochemical mechanisms of light therapy in order to better direct future studies. The implication of cytochrome c oxidase as the photoacceptor modulating light therapy is reviewed, as are the predominant hypotheses of the biochemical pathways involved in the stimulation of wound healing, cellular proliferation, production of transcription factors and other reported stimulatory effects.
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