Journal
EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 236, Issue 3, Pages 253-267Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1258/ebm.2010.010278
Keywords
T-cell epitope; MHC; method; immunological diagnosis; therapy; vaccine development
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Funding
- National Natural Science Foundation of China (NSFC) [81021003, 31030030]
- China National Grand S&T Special Project [2009ZX10004-201, -305]
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Immunogenic T-cell epitopes have a central role in the cellular immunity against pathogens and tumors. However, in the early stage of cellular immunity studies, it was complicated and time-consuming to identify and characterize T-cell epitopes. Currently, the epitope screening is experiencing renewed enthusiasm due to advances in novel techniques and theories. Moreover, the application of T-cell epitope-based diagnoses for tuberculosis and new data on epitope-based vaccine development have also revived the field. There is a growing knowledge on the emphasis of epitope-stimulated T-cell immune responses in the elimination of pathogens and tumors. In this review, we outline the significance of the identification and characterization of T-cell epitopes. We also summarize the methods and strategies for epitope definition and, more importantly, address the relevance of cytotoxic T-lymphocyte epitopes to clinical diagnoses, therapy and vaccine development.
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