Journal
EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 236, Issue 11, Pages 1231-1238Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1258/ebm.2011.011132
Keywords
fluorescence; carbon dots; quantum dots; cytotoxicity; cell imaging
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Funding
- National Institutes of Health
- National Science Foundation
- Susan G. Komen for the Cure Postdoctoral Fellowship
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [0967423] Funding Source: National Science Foundation
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Nanoscale carbon particles have emerged as versatile precursors for a new class of highly fluorescent nanomaterials that resemble semiconductor quantum dots. The surface-passivated fluorescent carbon nanoparticles, dubbed 'carbon dots', were already demonstrated for their potential optical bioimaging applications in vitro and in vivo. In this study, we conducted a systematic cytotoxicity evaluation on the carbon dots prepared by various combinations of precursor carbon nanoparticles and molecules for the particle surface functionalization. The results suggested that the cytotoxicity of carbon dots was dependent on the selection of surface passivation molecules. Those dots showing more significant cytotoxicity at higher concentrations were also evaluated for their effects on the fluorescence imaging of live cells. The implications of the results on the eventual use of carbon dots as cell imaging agents are discussed.
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