Journal
EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 233, Issue 2, Pages 109-122Publisher
SAGE PUBLICATIONS LTD
DOI: 10.3181/0707-MR-190
Keywords
fibrosis; collagen type I; fibrocytes; inflammation; EMT
Categories
Ask authors/readers for more resources
Fibrogenesis is a mechanism of wound healing and repair. However, prolonged injury causes deregulation of normal processes and results in extensive deposition of extracellular matrix (ECM) proteins and fibrosis. The current review will discuss similarities and differences of fibrogenesis in different organs and systems and focus on the origin of collagen producing cells. Although the relative contribution will vary in different tissues and different injuries, there are three general sources of fibrogenic cells: endogenous fibroblasts or fibroblast-like cells, epithelial to mesenchymal transition, and recruitment of fibrocytes from the bone marrow.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available