Journal
EXPERIMENTAL ANIMALS
Volume 63, Issue 4, Pages 357-365Publisher
INT PRESS EDITING CENTRE INC
DOI: 10.1538/expanim.14-0026
Keywords
acrosome reaction; fertilization; gene-manipulated animals; live imaging; sperm-egg fusion
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Despite numerous studies on mammalian fertilization, the mechanisms of fertilization-including the timing of acrosome reaction-remain largely unknown; more accurately described, the classical theory built upon years of layered experimental data is being challenged by recent conflicting evidence provided by gene-manipulated animals. Although in vitro fertilization remains our central research tool, the classical theory's decline reminds us of the importance of in vivo observations. Here, I describe the essential roles of gene-manipulated animals in elucidating the mechanism of fertilization and the pitfalls of in vitro fertilization studies trapping many researchers.
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