Journal
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
Volume 65, Issue 5, Pages 591-593Publisher
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.etp.2012.06.001
Keywords
Prochloraz; Fungicide; Antiandrogen; Perinatal exposure; Social recognition test; Social memory
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Funding
- Danish Council for Independent Research/Medical Sciences [SSVF 2107-04-0006]
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Metabolites of the commonly used imidazole fungicide prochloraz are androgen receptor antagonists. They have been shown to block androgen-driven development and compromise reproductive function. We tested the effect of prochloraz on cognitive behavior following exposure to this fungicide during the perinatal period. Pregnant Wistar rats were administered a 200 mg/kg dose of prochloraz on gestational day (GD) 7, GD11, and GD15. The social recognition test (SRT) was performed on 7-week-old male rat offspring. We found an increase in pregnancy length and a significantly reduced pup weight on PND15 and PND40 but no effect of prenatal prochloraz exposure on social investigation or acquisition of social-olfactory memory. (C) 2012 Elsevier GmbH. All rights reserved.
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