Journal
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
Volume 64, Issue 3, Pages 181-186Publisher
ELSEVIER GMBH
DOI: 10.1016/j.etp.2010.08.004
Keywords
Quice seed mucilage; T-2 Toxin; Dermal toxicity; Rabbit
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Funding
- Ahvaz Jundishapur University of Medical Sciences
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This study was performed to examine the healing effects of creams prepared from quince seed mucilage on dermal toxicity induced by T-2 toxin. Creams were prepared from quince seed mucilage in eucerin base as 5, 10, and 15% (w/w). To induce dermal toxicity, 100 mu g T-2 toxin was dissolved in 12 mu l methanol and applied on the shaved skin of rabbit for 2 consecutive days. A separate group received only solvent (methanol). On the third day, the prepared creams were applied on the skin lesions twice a day until complete healing was occurred. Healing, was defined by decreased wound margin, treatment erythema and blisters. Time required for healing was 14, 14, 12, 10, and 9 days for groups of no treatment, eucerin, quince seed cream 5%, 10%, and 15%, respectively. Results obtained by this study shows that quince seed mucilage (15%) has more and better healing effects on dermal toxicity caused by T-2 toxin comparing to no treatment or eucerin cream without mucilage. (C) 2010 Elsevier GmbH. All rights reserved.
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