Journal
EXPERIMENTAL AND MOLECULAR PATHOLOGY
Volume 96, Issue 3, Pages 422-425Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yexmp.2014.04.009
Keywords
Irritable bowel syndrome; MicroRNA; hsa-miRNA-150; hsa-miR-342-3p
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Funding
- U.S. Department of Health and Human Services
- National Institutes of Health
- National Institute of Nursing Research
- Division of Intramural Research [1ZIANR000018-01-04]
- Intramural Research Training Awards
- National Institute on Minority Health and Health Disparities [1K22MD006143-01]
- NIH Research Scholar RMP
- Burroughs Wellcome Fund
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Background and aims: MicroRNAs (miRNAs) are small non-coding RNAs, which regulate gene expression and are thus of interest as diagnostic markers, and as clues to etiology and targets of intervention. This pilot study examined whether circulating miRNAs are differentially expressed in patients with IBS. Methods: miRNA microarrays (NanoString) were run on the whole blood of 43 participants. Results: hsa-miR-150 and hsa-miR-342-3p were found to be significantly elevated (FDR adjusted p <= 0.05, >= 1.6 fold change) in IBS patients compared to healthy controls. Neither of these miRNAs showed any relationship to race or sex. hsa-miR-150 is associated with inflammatory bowel disorders and pain, and interacts with a protein kinase (AKT2) through which it may affect inflammatory pathways. hsa-miR-342-3p is predicted to interact with mRNAs involved in pain signaling, colonic motility, and smooth muscle function. Conclusions: This preliminary study reports the association of two miRNAs, detected in whole blood, with IBS. These miRNAs link to pain and inflammatory pathways both of which are thought to be dysregulated in IBS. Larger sample sizes are needed to confirm their importance and potential as biomarkers. Published by Elsevier Inc.
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