4.5 Article

Imaging Mass Spectrometry: Enabling a New Age of Discovery in Biology and Medicine Through Molecular Microscopy

Journal

Publisher

SPRINGER
DOI: 10.1007/s13361-015-1108-z

Keywords

Imaging; MALDI MS; Mass spectrometry; Molecular microscopy

Funding

  1. NIGMS NIH HHS [P41 GM103391, R01 GM058008] Funding Source: Medline

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Imaging mass spectrometry (IMS) has become a valuable tool for the production of molecular maps in samples ranging from solid inorganic materials to biologicals such as cells and tissues. The unique features of IMS are its ability to map a wide variety of different types of molecules, its superb molecular specificity, and its potential for discovery since no target-specific reagents are needed. IMS has made significant contributions in biology and medicine and promises to be a next generation tool in anatomic pathology.

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