Journal
EXPERIMENTAL AND MOLECULAR PATHOLOGY
Volume 90, Issue 1, Pages 74-78Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yexmp.2010.10.004
Keywords
Treg; Th17; Fibroblast; Cardiac fibrosis; MMP
Categories
Funding
- NSFC in China [30800481]
- Youth Special Science and Technology Foundation in Heilongjiang Province [QC07C84]
- Doctor Foundation of the Ministry of Education [20070226005]
- science and technology in Heilongjiang Education Bureau [11531171]
- Department of Health of Heilongjiang Province [2007-154]
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Cardiac fibrosis is defined as a progressive accumulation of fibrillar extracellular matrix (ECM) in the myocardium. The regulation of extracellular matrix remodeling is primarily mediated by cardiac fibroblasts (CF). Evidences suggest that various T lymphocyte phenotypes differentially affect organ fibrosis through modulating CF collagen and MMP/TIMP gene expression, MMP activity and cardiac collagen cross-linking, leading to altered ECM composition. In regard to the importance of cytokines in cardiac fibrosis and heart failure, in this review, we will address the role of different T cell subsets in inflammation-mediated cardiac fibrosis, from a distinct perspective of T cell and fibroblast interaction. We conclude that in addition to preventive strategies, therapies based on deviation of Th1/Th2 paradigm, and manipulation of Tregs and Th17 would show promising results in future studies. Crown Copyright (C) 2010 Published by Elsevier Inc. All rights reserved.
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