Journal
ANNALS OF NEUROLOGY
Volume 78, Issue 2, Pages 317-322Publisher
WILEY-BLACKWELL
DOI: 10.1002/ana.24432
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Funding
- Dana Foundation Clinical Neuroscience Program
- Ministry of Science and Technology of Taiwan
- National Science Council of Taiwan [NSC 102-2911-I-008-001, NSC 103-2917-I-564-005, NSC 102-2221-E-008-008, NSC 103-2221-E-008-006-MY3]
- Ministry of Science and Technology of Taiwan Center for Dynamical Biomarkers and Translational Medicine
- CGH-NCU Joint Research Foundation [CNJRF-101CGH-NCU-A4, VGHUST103-G1-3-3]
- US National Institutes of Health grants from the National Institute of Aging [R01AG042210, R01AG017917, P01AG009975]
- National Heart Lung and Blood Institute [P01HL095491, R00HL102241]
- National Institute of Neurological Disorders and Stroke [R01NS072337, R01078009]
- Canadian Institutes of Health Research [MOP125934, MMC132692]
- Illinois Department of Public Health
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL095491, R00HL102241] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS078009, R01NS072337] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [P01AG009975, R01AG042210, R01AG017917] Funding Source: NIH RePORTER
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The suprachiasmatic nucleus (SCN) of the hypothalamus, the master mammalian circadian pacemaker, synchronizes endogenous rhythms with the external day-night cycle. Older humans, particularly those with Alzheimer disease (AD), often have difficulty maintaining normal circadian rhythms compared to younger adults, but the basis of this change is unknown. We report that the circadian rhythm amplitude of motor activity in both AD subjects and age-matched controls is correlated with the number of vasoactive intestinal peptide-expressing SCN neurons. AD was additionally associated with delayed circadian phase compared to cognitively healthy subjects, suggesting distinct pathologies and strategies for treating aging- and AD-related circadian disturbances. Ann Neurol 2015;78:317-322
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