Journal
EXPERIMENTAL AND MOLECULAR PATHOLOGY
Volume 84, Issue 2, Pages 79-89Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yexmp.2007.12.002
Keywords
ErbB receptors; human pathology; cancer prognosis
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Changes in the expression of cellular receptors contribute to the progression of many types of solid tumors. In this review, we focus on the normal role of ErbB receptors as signal transducers and their contribution to carcinogenesis when there are abnormalities in ErbB signaling due to the overactivity of the receptors or the overexpression of ligands, which can lead to developmental defects and have been associated with many types of cancers. (C) 2007 Elsevier Inc. All rights reserved.
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