Journal
EXPERIMENTAL AND MOLECULAR MEDICINE
Volume 43, Issue 1, Pages 1-6Publisher
NATURE PUBLISHING GROUP
DOI: 10.3858/emm.2011.43.1.007
Keywords
CD4-positive T-lymphocytes; cell differentiation; cytokines; Th17 cells; transcription factors
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CD4(+) T lymphocytes play a major role in regulation of adaptive immunity. Upon activation, naive T cells differentiate into different functional subsets. In addition to the classical Th1 and Th2 cells, several novel effector T cell subsets have been recently identified, including Th17 cells. There has been rapid progress in characterizing the development and function of Th17 cells. Here I summarize and discuss on the genetic controls of their differentiation and emerging evidence on their plasticity. This information may benefit understanding and treating immune diseases.
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