Journal
EXPERIMENTAL AND MOLECULAR MEDICINE
Volume 40, Issue 1, Pages 52-58Publisher
NATURE PUBLISHING GROUP
DOI: 10.3858/emm.2008.40.1.52
Keywords
macrophages; NF-kappa B; osteodasts; RANK ligand; reactive oxygen species; rutin; tumor necrosis factor alpha
Funding
- National Research Foundation of Korea [R01-2007-000-21082-0, 과06B1212] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Rutin, a glycoside of flavonol, inhibits osteoclast formation induced by receptor activator of NF-kappa B ligand (RANKL) in bone marrow-derived macrophages. It reduces reactive oxygen species produced by RANKL and its inhibitory effect results from reduced levels of TNF-alpha. Rutin also lowers NF-kappa B activation in response to RANKL.
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