Journal
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
Volume 118, Issue 10, Pages 757-759Publisher
JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
DOI: 10.1055/s-0030-1249686
Keywords
immunology; C-reactive protein; interleukin-6; tumor necrosis factor-alpha; exercise; genes
Categories
Funding
- Finnish Ministry of Education, Sigrid Juselius Foundation
- Academy of Finland [209 445, 211 497]
- EVO [5 179, 5198]
- Finnish Funding Agency for Technology and Innovation [70103/06]
- Finnish Foundation for Diabetes Research
- European Foundation for the Study of Diabetes
- Juho Vainio Foundation
- German Federal Ministry of Health
- Ministry of Innovation, Science, Research and Technology of the State North Rhine-Westphalia
- German Diabetes Foundation (Deutsche Diabetes-Stiftung)
- Department of Internal Medicine II-Cardiology at the University of Ulm
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Physical activity exerts anti-inflammatory effects, but genetic variation may modify its influence. In particular, the rs1800629 single-nucleotide polymorphism (SNP) in the tumor necrosis factor (TNF) gene and the rs1800795 SNP in the interleukin-6 (IL6) gene have been found to modify the effect of exercise training on circulating levels of C-reactive protein (CRP) and IL-6, respectively. We assessed whether rs1800629 and rs1800795 modified the effect of moderate-to-vigorous physical activity on changes in serum levels of high-sensitivity CRP and IL-6 in the Finnish Diabetes Prevention Study (DPS). Genotype and year data on changes in physical activity, serum CRP and IL-6 were available for 390 overweight subjects with impaired glucose tolerance. The rs1800629 SNP in TNF interacted with the 1-year change in moderate-to-vigorous physical activity on changes in CRP among those who had high (>= 3 mg/L) baseline CRP levels (P=0.034 for interaction). Carriers of the GG genotype showed a greater decrease in CRP with increasing physical activity than the individuals with the A allele. No interaction between the rs1800795 SNP in IL6 and changes in moderate-to-vigorous physical activity on the 1-year change in serum IL-6 was found. In conclusion, the rs1800629 SNP in the TNF gene may modify the effect of moderate-to-vigorous physical activity on serum levels of CRP.
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