Polymorphisms in Perilipin Gene (PLIN) are not Associated with Obesity and Weight Variation in People with High Risk of Type 2 Diabetes

Perilipins ire homonally regulated phosphorylated proteins that coat the intracellular lipid storage droplet [1]. They are essential for the regulation of triglyceride deposition and mobilization [2,3]. The human perilipin gene (PLIN) is located to 15q26.1, near the Susceptibility loci for obesity, and insulin-dependent diabetes mellitus, and hypertriglyceridemia. Therefore, it is considered as a candidate gene for these diseases [4]. Some Studies shown that lower level of perilipin protein was displayed in obese than lean Subjects [5] and polymorphisms in PLIN were associated with obesity in American and Spanish white women as well as in Korean [6,7]. But some other Studies showed that, this association was not significant in Chinese [8] and French [9]. The aim Of the Current study was to examine whether the associations manifested in a German population With high risk of type 2 diabetes.