Journal
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
Volume 116, Issue -, Pages S40-S45Publisher
JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
DOI: 10.1055/s-2008-1081496
Keywords
diabetic cardiomyopathy; lipotoxicity; cardiac metabolism
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With the rapidly increasing prevalence of type 2 diabetes mellitus the risk for cardiovascular events is increasing. Almost 2 of 3 patients who present with symptomatic CHD have abnormal glucose homeostasis. Patients with diabetes mellitus and cardiovascular disease hive all unfavourable prognosis. The most important result of diabetes metabolism is the switch from carbohydrates and fatty acids as a Source of energy to ail excessive use of fatty acids. The adverse influence of diabetes mellitus extends to all components of the cardiovascular system, including microvasculature, the epicardial coronary arteries, the large conduit arteries and the heart, as well as the kidneys. Focus Of this review is the myocardial metabolism in heart failure and diabetes mellitus.
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