Journal
EXPERIMENTAL AGING RESEARCH
Volume 35, Issue 1, Pages 61-82Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/03610730802545051
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Funding
- National Institute on Aging [R01AG17917, R01AG24480]
- Illinois Department of Public Health
- Robert C. Borwell Endowment Fund
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The authors developed and validated a continuous composite measure of frailty and examined its rate of change in 832 older persons with annual evaluations for up to 8 years. In generalized estimating equation models adjusted for age, sex, and education, there was a significant increase in frailty during follow-up. In a proportional hazards model controlling for age, sex, education, and baseline frailty, each 1-unit increase in annual change in frailty was associated with an almost 5 times the risk of mortality. Using a continuous measure, the authors document that frailty is progressive in some older persons and that its rate of progression is associated with mortality.
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