Journal
EXERCISE AND SPORT SCIENCES REVIEWS
Volume 42, Issue 2, Pages 45-52Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1249/JES.0000000000000012
Keywords
muscle atrophy; myosin heavy-chain coexpression; denervation; skeletal muscle; fiber type; aging; sarcopenia
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Funding
- Canadian Institutes of Health Research [MOP125986, MOP119583]
- Fonds de Recherche Quebec-Sante
- McGill University
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It is accepted widely that fast-twitch muscle fibers are preferentially impacted in aging muscle, yet we hypothesize that this is not valid when aging muscle atrophy becomes severe. In this review, we summarize the evidence of fiber type-specific effect in aging muscle and the potential confounding roles of fibers coexpressing multiple myosin heavy-chain isoforms and their histochemical identification.
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