Journal
EXERCISE AND SPORT SCIENCES REVIEWS
Volume 41, Issue 2, Pages 100-106Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JES.0b013e318275d230
Keywords
cytokines; myokines; fatigue; oxidative muscle; atrophy; hypertrophy
Categories
Funding
- National Institute of Arthritis and Musculoskeletal and Skin Diseases [5T32AR053461]
- Department of Veterans Affairs [BX001026]
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PISTILLI, E. E. and L. S. QUINN. From anabolic to oxidative: reconsidering the roles of IL-15 and IL-15R alpha in skeletal muscle. Exerc. Sport Sci. Rev., Vol. 41, No. 2, pp. 100-106, 2013. Interleukin 15 (IL-15) and its receptor IL-15 receptor-alpha (IL-15R alpha) are suggested to function in the determination of skeletal muscle phenotypes, with IL-15 originally proposed as an anabolic cytokine. This review will focus on recent work demonstrating that manipulation of IL-15 and IL-15R alpha in vivo promotes changes in exercise capacity, muscle fatigue, and gene expression indicative of a more oxidative skeletal muscle phenotype.
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