Journal
EXERCISE AND SPORT SCIENCES REVIEWS
Volume 40, Issue 2, Pages 73-78Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JES.0b013e31824580c6
Keywords
connectin; force enhancement; force depression; history dependence; sliding filament theory; thin filament rotation; titin-actin interactions
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Funding
- National Science Foundation [IOS-0623791, IOS-0732949, IIS-0827688, IOS-1025806]
- Northern Arizona University
- Direct For Computer & Info Scie & Enginr
- Div Of Information & Intelligent Systems [0827688] Funding Source: National Science Foundation
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [1025806] Funding Source: National Science Foundation
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MONROY, J.A., K.L. POWERS, L.A. GILMORE, T.A. UYENO, S.L. LINDSTEDT, and K.C. NISHIKAWA. What is the role of titin in active muscle? Exerc. Sport Sci. Rev., Vol. 40, No. 2, pp. 73-78, 2012. Several properties of muscle defy explanation solely based on the sliding filament-swinging cross-bridge theory. Indeed, muscle behaves as though there is a dynamic spring'' within the sarcomeres. We propose a new winding filament'' mechanism for how titin acts, in conjunction with the cross-bridges, as a force-dependent spring. The addition of titin into active sarcomeres resolves many puzzling muscle characteristics.
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