Journal
EXERCISE AND SPORT SCIENCES REVIEWS
Volume 39, Issue 1, Pages 23-33Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JES.0b013e318201f39d
Keywords
immune risk profile; cytomegalovirus; lymphocyte apoptosis; T cell; immunology
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- University of Houston
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SIMPSON, R.J. Aging, persistent viral infections, and immunosenescence: can exercise make space''? Exerc. Sport Sci. Rev., Vol. 39, No. 1, pp. 23-33, 2011. Overcrowding the immune space with excess clones of viral-specific T cells causes the naive T-cell repertoire to shrink, which increases infection susceptibility to novel pathogens. Physical exercise preferentially mobilizes senescent T cells from the peripheral tissues into the blood, which might facilitate their subsequent apoptosis and create vacant space'' for newly functional T cells to occupy and expand the naive T-cell repertoire.
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