Journal
EXERCISE AND SPORT SCIENCES REVIEWS
Volume 39, Issue 3, Pages 128-132Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JES.0b013e3182141f80
Keywords
senescence; bioenergetics; mitochondria; aging; caloric restriction; cardiovascular disease; phytochemicals
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Funding
- American Diabetes Association
- American Federation for Aging Research
- University of Oklahoma College of Medicine Alumni Association
- National Institutes of Health [AG031085, AT006526, HL077256, AG031182, P01 AG11370]
- National Institute on Aging
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UNGVARI, Z., W. E. SONNTAG, R. DE CABO, J.A. BAUR, and A. CSISZAR. Mitochondrial protection by resveratrol. Exerc. Sport. Sci. Rev., Vol. 39, No. 3, pp. 128-132, 2011. Mitochondrial dysfunction and oxidative stress are thought to play important roles in mammalian aging. Resveratrol is a plant-derived polyphenol that exerts diverse antiaging activities, mimicking some of the molecular and functional effects of dietary restriction. This review focuses on the molecular mechanisms underlying the mitochondrial protective effects of resveratrol, which could be exploited for the prevention or amelioration of age-related diseases in the elderly.
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