4.5 Review

Overcoming Barriers to Progress in Exercise Genomics

Journal

EXERCISE AND SPORT SCIENCES REVIEWS
Volume 39, Issue 4, Pages 212-217

Publisher

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JES.0b013e31822643f6

Keywords

exercise genomics; candidate genes; single nucleotide polymorphism; genome-wide association study; genomic predictors

Funding

  1. National Institutes of Health [HL-45670]
  2. John W. Barton, Sr. Chair in Genetics and Nutrition

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BOUCHARD, C. Overcoming barriers to progress in exercise genomics. Exerc. Sports Sci. Rev., Vol. 39, No. 4, pp. 212-217, 2011. This commentary focuses on the issues of statistical power, the usefulness of hypothesis-free approaches such as in genome-wide association explorations, the necessity of expanding the research beyond common DNA variants, the advantage of combining transcriptomics with genomics, and the complexities inherent to the search for links between genotype and phenotype in exercise genomics research.

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