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Skeletal Muscle Injury Versus Adaptation with Aging: Novel Insights on Perplexing Paradigms

Journal

EXERCISE AND SPORT SCIENCES REVIEWS
Volume 38, Issue 1, Pages 10-16

Publisher

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JES.0b013e3181c5cd7c

Keywords

mechanical loading; stretch shortening contractions; high-intensity resistance training; muscle adaptation; myofiber degeneration; myofiber regeneration; inflammation

Funding

  1. Internal NIOSH

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BAKER, B.A. and R.G. CUTLIP. Skeletal muscle injury versus adaptation with aging: novel insights on perplexing paradigms. Exerc. Sport Sci. Rev., Vol. 38, No. 1, pp. 10-16, 2010. A growing body of data supports a view that skeletal muscle's response after mechanical loading does not always result in the classically reported injury response. Furthermore, current evidence supports a model of muscle adaptation and/or maladaptation, distinct from overt injury, in which myofiber degeneration and inflammation do not contribute as significantly as once reported even in aged populations.

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