Why Eating Less Keeps Mitochondria Working in Aged Skeletal Muscle

HEPPLE, R.T. Why eating less keeps mitochondria working in aged skeletal muscle. Exerc. Sport Sci. Rev., Vol. 37, No. 1, pp. 23-28, 2009. The mechanisms by which caloric restriction preserves skeletal muscle health with aging continue to be explored; however, mounting evidence points toward a convergence of effects at the level of the mitochondrion. Specifically, caloric restriction reduces mitochondrial reactive oxygen species production and promotes mitochondrial renewal via enhanced drive on mitochondrial biogenesis and autophagy.