Journal
EXERCISE AND SPORT SCIENCES REVIEWS
Volume 36, Issue 4, Pages 179-186Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JES.0b013e3181877e13
Keywords
sarcopenia; aging; loading; hypertrophy; fiber type; translation; protein synthesis
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Funding
- American Federation
- NIH [AG025101]
- NATIONAL INSTITUTE ON AGING [R15AG025101] Funding Source: NIH RePORTER
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The activity of 5'-adenosine monophosphate (AMP)-activated protein kinase (AMPK), a negative regulator of cell size, is up-regulated with, age in resting and overloaded fast-twitch skeletal muscle but not slow-twitch muscle. Here, we provide evidence to support the hypothesis that elevated AMPK activity plays a potentially important integrative role in the age-related atrophy and diminished capacity for growth specific to fast-twitch skeletal muscle.
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