Journal
EXERCISE AND SPORT SCIENCES REVIEWS
Volume 36, Issue 3, Pages 122-127Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JES.0b013e31817bfd47
Keywords
skin blood flow; aging; temperature regulation; adrenergic; Rho kinase; cold
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Funding
- NIA NIH HHS [R01 AG007004] Funding Source: Medline
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Human exposure to cold stimulates cutaneous vasoconstriction by activating both sympathetic reflex and locally mediated pathways. Older humans are vulnerable to hypothermia because primary aging impairs thermoregulatory cutaneous vasoconstriction. This article highlights recent findings discussing how age-related decrements in sympathetic neuro transmission contribute directly to thermoregulatory impairment, whereas changes in local cold-induced intracellular signaling suggest a more generalized age-associated vascular dysfunction.
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