Journal
EXERCISE AND SPORT SCIENCES REVIEWS
Volume 36, Issue 4, Pages 187-192Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JES.0b013e31818782dd
Keywords
NSCL-2; linkage analysis; knockout mice; muscle; hypothalamus
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Funding
- National Institute of Diabetes and Digestive Disorders [DK-59903]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK059903] Funding Source: NIH RePORTER
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In mice, targeted deletion of the basic helix-loop-helix transcription factor, nescient helix-loop-helix 2 (Nhlh2), leads to adult-onset obesity and reduced physical activity. We propose the novel hypothesis that transcriptional activity by Nhlh2 (NHLH2 in humans) controls either the ability or the motivation for exercise.
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