Journal
ANNALS OF NEUROLOGY
Volume 77, Issue 3, Pages 541-546Publisher
WILEY-BLACKWELL
DOI: 10.1002/ana.24342
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Funding
- Canadian Institutes of Health Research [8109, 74609, MOP119340]
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Seizures in temporal lobe epilepsy can be classified as hypersynchronous and low-voltage fast according to their onset patterns. Experimental evidence suggests that low-voltage fast-onset seizures mainly result from the synchronous activity of -aminobutyric acid-releasing cells. In this study, we tested this hypothesis using the optogenetic control of parvalbumin-positive interneurons in the entorhinal cortex, in the in vitro 4-aminopyridine model. We found that both spontaneous and optogenetically induced seizures had similar low-voltage fast-onset patterns. In addition, both types of seizures presented with higher ripple than fast ripple rates. Our data demonstrate the involvement of interneuronal networks in the initiation of low-voltage fast-onset seizures. Ann Neurol 2015;77:541-546
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