Journal
EXERCISE AND SPORT SCIENCES REVIEWS
Volume 36, Issue 3, Pages 116-121Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JES.0b013e31817be7b7
Keywords
atrophy; sarcopenia; exercise; reactive oxygen species; mitochondrial myopathy; apoptosis; mitochondrial permeability transition pore
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Apoptosis is an essential process that plays a critical role in both tissue development and maintenance. Apoptosis has been shown to be involved in skeletal muscle atrophy resulting from chronic muscular disuse, sarcopenia, and mitochondrial myopathies. Exercise may attenuate some of the proapoptotic adaptations that occur during these conditions. This review will focus on the factors influencing mitochondrially mediated apoptosis in skeletal muscle.
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