Journal
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
Volume 2013, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2013/952796
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Funding
- National Research Institute of Chinese Medicine, Taipei, Taiwan
- National Science Council Taiwan [NSC99-2113-M- 010-001-MY3, NSC99-2628-B-010-008-MY3]
- Committee on Chinese Medicine and Pharmacy, Department of Health Taiwan [CCMP101-CP-015]
- Taipei City Hospital, Taipei, Taiwan [TCH 102-02, 10102-62-084]
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This study develops several chemical and physical methods to evaluate the quality of a traditional Chinese formulation, Jia-Wei-Xiao-Yao-San. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) coupled with electrospray ionization was used to measure the herbal biomarkers of saikosaponin A, saikosaponin D, ferulic acid, and paeoniflorin from this herbal formula. A scanning electron microscope (SEM) and light microscopy photographs with Congo red staining were used to identify the cellulose fibers if rawherbal powder had been added to the herbal pharmaceutical product. Moreover, water solubility and crude fiber content examination were used to inspect for potential herbal additives to the herbal pharmaceutical products. The results demonstrate that the contents of the herbal ingredients of saikosaponin A, saikosaponin D, ferulic acid, and paeoniflorin were around 0.351 +/- 0.017, 0.136 +/- 0.010, 0.140 +/- 0.005, and 2.281 +/- 0.406mg/g, respectively, for this herbal pharmaceutical product. The physical examination data demonstrate that the rawherbal powder had rough, irregular, lumpy, filamentous, and elongated shapes, as well as strong Congo red staining. In addition, water solubility and crude fiber content were not consistent in the herbal pharmaceutical products.
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