Journal
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
Volume 2012, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2012/373219
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Funding
- National Natural Science Foundation [30701070]
- Scientific and Technological Project of Shanghai [11DZ1971702]
- Wang Bao-En Hepatic Fibrosis Research Fund [20100048]
- Shanghai Rising-Star Program [08QA1406200]
- Xinglin Scholars Program of Shanghai University of Traditional Chinese Medicine
- E-institute of Shanghai Municipal Education Commission [E03008]
- Shanghai Municipal Education Commission
- Shanghai Key Laboratory of Traditional Chinese Clinical Medicine
- Key Disciplines of Liver and Gall Bladder Diseases of State Administration of Traditional Chinese Medicine of the People's Republic of China
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To discover and develop novel natural compounds with therapeutic selectivity or that can preferentially kill cancer cells without significant toxicity to normal cells is an important area in cancer chemotherapy. Kushen, the dried roots of Sophora flavescens Aiton, has a long history of use in traditional Chinese medicine to treat inflammatory diseases and cancer. Kushen alkaloids (KS-As) and kushen flavonoids (KS-Fs) are well-characterized components in kushen. KS-As containing oxymatrine, matrine, and total alkaloids have been developed in China as anticancer drugs. More potent antitumor activities were identified in KS-Fs than in KS-As in vitro and in vivo. KS-Fs may be developed as novel antitumor agents.
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