Journal
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
Volume 2011, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2011/352938
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Funding
- University of Buenos Aires [B030, 20020090300115]
- Consejo Nacional de Investigaciones Cientificas y Tecnicas [PIP 01540]
- Programa Iberoamericano de Ciencia y Tecnologia para el Desarrollo [X5]
- Flora Regional OEA project
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The in vitro antiplasmodial activity of Ambrosia tenuifolia organic extract and its isolated sesquiterpene lactones, psilostachyin and peruvin, has been evaluated against Plasmodium falciparum F32 and W2 strains. The cytotoxicity of both compounds was determined on lymphoid cells, and their corresponding selectivity indexes (SIs) were calculated. Peruvin was the most active compound on F32 strain of P. falciparum with a 50% inhibitory concentration value (IC50) of 0.3 mu g/mL (1.1 mu M) whereas psilostachyin showed activity on both strains (IC50 = 0.6 (2.1 mu M) and 1.8 mu g/mL (6.4 mu M)). Fifty percent cytotoxic concentration (CC50) values (48 h) were 6.8 mu g/mL (24.3 mu M) and 10.0 mu g/mL (37.9 mu M) for psilostachyin and peruvin, respectively.
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