4.5 Article

Seroepidemiology of Middle East respiratory syndrome (MERS) coronavirus in Saudi Arabia (1993) and Australia (2014) and characterisation of assay specificity

Journal

EUROSURVEILLANCE
Volume 19, Issue 23, Pages 2-7

Publisher

EUR CENTRE DIS PREVENTION & CONTROL
DOI: 10.2807/1560-7917.ES2014.19.23.20828

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Funding

  1. Deanship of Research of the College of Veterinary Medicine, King Faisal University [143011]
  2. European Community under project European management Platform for Emerging and Re-emerging Disease entities (EMPERIE) [223498]
  3. National Institute of Allergy and Infectious Diseases, National Institutes of Health [HHSN266200700005C]

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The pseudoparticle virus neutralisation test (ppNT) and a conventional microneutralisation (MN) assay are specific for detecting antibodies to Middle East respiratory syndrome coronavirus (MERS-CoV) when used in seroepidemiological studies in animals. Genetically diverse MERS-CoV appear antigenically similar in MN tests. We confirm that MERS-CoV was circulating in dromedaries in Saudi Arabia in 1993. Preliminary data suggest that feral Australian dromedaries may be free of MERS-CoV but larger confirmatory studies are needed.

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