Journal
ANNALS OF NEUROLOGY
Volume 77, Issue 5, Pages 895-901Publisher
WILEY-BLACKWELL
DOI: 10.1002/ana.24384
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Funding
- Fondo de Investigaciones Sanitarias from the Instituto de Salud Carlos III (ISCIII)
- FEDER (European Union) [PS09/01038]
- Institut d'Investigacions Biomediques August Pi i Sunyer
- European Commission
- Spanish Ministry of Economy and Competitiveness (MINECO)
- ISCIII
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Recently, we reported downregulated circulating levels of the microRNAs miR-19b, miR-29a, and miR-29c in Parkinson disease. Here we investigated the expression of these microRNAs in serum samples from 56 patients with idiopathic rapid eye movement sleep behavior disorder, before and after their conversion into a synucleinopathy. Compared to controls, we found that the expression level of miR-19b is downregulated in patients with idiopathic rapid eye movement sleep behavior disorder and antedates the diagnosis of Parkinson disease and dementia with Lewy bodies after 4.67 +/- 2.61 years of follow-up. Our findings indicate that dysregulation of the microRNA miR-19b occurs in the prodromal stage of synucleinopathies. Ann Neurol 2015;77:895-901
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